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Steric interactions also cause a slight bending or contraction of the peptide chains, and this results in a puckered distortion (the pleated sheet)

The research, published in the Journal of Endocrinology and Metabolism, found that the peptide had no effect on serum IGF-1 levels, no negative effect on carbohydrate metabolism, and no anti-AOD-9604 antibodies were detected in any patients